Relationship between cranial defect and physiology of cerebrospianl fluid
An experimental study in rabbits.

Ersin Erdogan, MD, Bulent Duz, MD, Ozgur Karacalioglu1, MD, MD, Erdener Timurkaynak, MD.
Departments of Neurosurgery, and Nuclear Medicine1, Gulhane Military School of Medicine, GATA, Ankara-TURKEY

E-mail: eerdogan@gata.edu.tr

 

The aim of this study was to investigate the impact of cranial defect on physiology of cerebrospinal fluid.

Eleven rabbits underwent a meticulous study of cerebrospinal fluid circulation as assessed by cisternography using 300 microcurie/0.1 cc Tc99mDTPA prior to and following creation of cranial defect. The rate of clearance of the pharmaceutical agent from cerebrospinal fluid was studied for each rabbit preoperatively and 24 hours, 7 days, 3 months postoperatively.

The correlation between the results was assessed with Wilcoxon Signed Ranks test and no statistical difference was found between the preoperative and postoperative values. These data suggest that the cerebrospinal fluid kinetics do not significantly change in large cranial defects.

Contains all the abstracts in .pdf format (201 Kb)